Publications 2025Luo Z, Wang H, Ge W, Wang Y, Zhou S, Jing R, Siddique MN, Ma X, Zheng H, Wang X. Chain Length Does Matter: Development of High-Potency QS-21-Based Vaccine Adjuvants. Journal of Medicinal Chemistry 68(2), 1511-1525 (2025). doi: 10.1021/acs.jmedchem.4c02173.Ekstrom TL, Rosok RM, Abdelrahman AM, Parassiadis C, Manjunath M, Dittrich MY, Wang X, Kutschat AP, Kanakan A, Rajput A, Schacherer N, Lukic T, Carlson DM, Thiel J, Kopp W, Stroebel P, Ellenrieder V, Gaedcke J, Dong M, Najafova Z, Truty MJ, Hessmann E, Johnsen SA. Glucocorticoid receptor suppresses GATA6-mediated RNA polymerase II pause release to modulate classical subtype identity in pancreatic cancer. Gut , gutjnl-334374 (2025). doi: 10.1136/gutjnl-2024-334374.Shah V, Giotopoulos G, Osaki H, Meyerhöfer M, Meduri E, Gallego-Crespo A, Behrendt MA, Saura-Pañella M, Tarkar A, Schubert B, Yun H, Horton SJ, Agrawal-Singh S, Haehnel PS, Basheer F, Lugo D, Eleftheriadou I, Barbash O, Dhar A, Kühn MWM, Guezguez B, Theobald M, Kindler T, Gallipoli P, Yeh P, Dawson MA, Prinjha RK, Huntly BJP, Sasca D. Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 coactivation. Blood 145(7), 748-764 (2025). doi: 10.1182/blood.2022019306. 2024Farr JN, Atkinson EJ, Achenbach SJ, Volkman TL, Tweed AJ, Vos SJ, Ruan M, Sfeir J, Drake MT, Saul D, Doolittle ML, Bancos I, Yu K, Tchkonia T, LeBrasseur NK, Kirkland JL, Monroe DG, Khosla S. Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial. Nature Medicine 30(9), 2605-2612 (2024). doi: 10.1038/s41591-024-03096-2.Kosinsky RL, Gonzalez MM, Saul D, Barros LL, Sagstetter MR, Fedyshyn Y, Nair A, Sun Z, Hamdan FH, Gibbons HR, Perez Pachon ME, Druliner BR, Johnsen SA, Faubion WA. The FOXP3+ Pro-Inflammatory T Cell: A Potential Therapeutic Target in Crohn’s Disease. Gastroenterology 166(4), 631-644.e17 (2024). doi: 10.1053/j.gastro.2024.01.007.Saul D, Doolittle ML, Rowsey JL, Froemming MN, Kosinsky RL, Vos SJ, Ruan M, LeBrasseur NK, Chandra A, Pignolo RJ, Passos JF, Farr JN, Monroe DG, Khosla S. Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair. Journal of Clinical Investigation 134(12) (2024). doi: 10.1172/JCI179834.Michelatti D, Beyes S, Bernardis C, Negri ML, Morelli L, Bediaga NG, Poli V, Fagnocchi L, Lago S, D’Annunzio S, Cona N, Gaspardo I, Bianchi A, Jovetic J, Gianesello M, Turdo A, D’Accardo C, Gaggianesi M, Dori M, Forcato M, Crispatzu G, Rada-Iglesias A, Sosa MS, Timmers HTM, Bicciato S, Todaro M, Tiberi L, Zippo A. Oncogenic enhancers prime quiescent metastatic cells to escape NK immune surveillance by eliciting transcriptional memory. Nature Communications 15(1), 2198-2198 (2024). doi: 10.1038/s41467-024-46524-0.Böpple K, Oren Y, Henry WS, Dong M, Weller S, Thiel J, Kleih M, Gaißler A, Zipperer D, Kopp H, Aylon Y, Oren M, Essmann F, Liang C, Aulitzky WE. ATF3 characterizes aggressive drug-tolerant persister cells in HGSOC. Cell Death & Disease 15(4), 290-290 (2024). doi: 10.1038/s41419-024-06674-x.Beigl TB, Paul A, Fellmeth TP, Nguyen D, Barber L, Weller S, Schäfer B, Gillissen BF, Aulitzky WE, Kopp H, Rehm M, Andrews DW, Pluhackova K, Essmann F. BCL-2 and BOK regulate apoptosis by interaction of their C-terminal transmembrane domains. EMBO Reports (2024). doi: 10.1038/s44319-024-00206-6.Yun H, Zoller J, Zhou F, Rohde C, Liu Y, Blank MF, Göllner S, Müller-Tidow C. The landscape of RNA-chromatin interaction reveals small non-coding RNAs as essential mediators of leukemia maintenance. Leukemia (2024). doi: 10.1038/s41375-024-02322-7.Yang M, Ma Z, Wang C, Agca MC, Liu H, Huang K, Glage S, Rumpel R, Gerbaulet A, Roers A, Liu X, Noyan F, von Neuhoff N, Ganser A, Liu L, Yun H, Li Z. Cre recombinase promotes leukemogenesis in the presence of both homozygous and heterozygous FLT3-ITD. Leukemia 38(6), 1437-1439 (2024). doi: 10.1038/s41375-024-02259-x.Ekstrom TL, Hussain S, Bedekovics T, Ali A, Paolini L, Mahmood H, Rosok RM, Koster J, Johnsen SA, Galardy PJ. USP44 overexpression drives a MYC-like gene expression program in neuroblastoma through epigenetic reprogramming. Molecular Cancer Research (2024). doi: 10.1158/1541-7786.MCR-23-0454.Blasi M, Kuon J, Lüders H, Misch D, Kauffmann-Guerrero D, Hilbrandt M, Kazdal D, Falkenstern-Ge RF, Hackanson B, Dintner S, Faehling M, Kirchner M, Volckmar AL, Kopp HG, Allgäuer M, Grohé C, Tufman A, Reck M, Frost N, Stenzinger A, Thomas M, Christopoulos P. First-line immunotherapy for lung cancer with MET exon 14 skipping and the relevance of TP53 mutations. European Journal of Cancer 199 (2024). doi: 10.1016/j.ejca.2024.113556.Hasselluhn MC, Schlösser D, Versemann L, Schmidt GE, Ulisse M, Oschwald J, Zhang Z, Hamdan F, Xiao H, Kopp W, Spitalieri J, Kellner C, Schneider C, Reutlinger K, Nagarajan S, Steuber B, Sastra SA, Palermo CF, Appelhans J, Bohnenberger H, Todorovic J, Kostyuchek I, Ströbel P, Bockelmann A, König A, Ammer-Herrmenau C, Schmidleitner L, Kaulfuß S, Wollnik B, Hahn SA, Neesse A, Singh SK, Bastians H, Reichert M, Sax U, Olive KP, Johnsen SA, Schneider G, Ellenrieder V, Hessmann E. An NFATc1/SMAD3/cJUN Complex Restricted to SMAD4-Deficient Pancreatic Cancer Guides Rational Therapies. Gastroenterology 166(2), 298-312.e14 (2024). doi: 10.1053/j.gastro.2023.10.026.Salega A, Münch M, Renner P, Thon K, Steurer W, Mönch D, Koch J, Maaß A, Schlitt HJ, Dahlke M, Leibold T. Late Local Recurrence after Neoadjuvant Therapy and Radical Resection for Locally Advanced Rectal Cancer. Cancers 16(2) (2024). doi: 10.3390/cancers16020448.Godfrey LK, Forster J, Liffers ST, Schröder C, Köster J, Henschel L, Ludwig KU, Lähnemann D, Trajkovic-Arsic M, Behrens D, Scarpa A, Lawlor RT, Witzke KE, Sitek B, Johnsen SA, Rahmann S, Horsthemke B, Zeschnigk M, Siveke JT. Pancreatic cancer acquires resistance to MAPK pathway inhibition by clonal expansion and adaptive DNA hypermethylation. Clinical Epigenetics 16(1) (2024). doi: 10.1186/s13148-024-01623-z.Bischoff P, Reck M, Overbeck T, Christopoulos P, Rittmeyer A, Lüders H, Kollmeier J, Kulhavy J, Kemper M, Reinmuth N, Röper J, Janning M, Sommer L, Aguinarte L, Koch M, Wiesweg M, Wesseler C, Waller CF, Kauffmann-Guerrero D, Stenzinger A, Stephan-Falkenau S, Trautmann M, Lassmann S, Tiemann M, Klauschen F, Sebastian M, Griesinger F, Wolf J, Loges S, Frost N, Hilbrandt M, Süptitz J, Grah C, Velthaus JL, Kopp HG, Schmidt B, Horter S, Keymel S, Aydilek E, Tritchkova G, Raspe M, Papić D, Florian S, Horst D, Wild PJ, Thomas M, Grohé C, Bleckmann A, Wermke M, Hummel HD, Stratmann J, Schütte W. Outcome of First-Line Treatment With Pembrolizumab According to KRAS/TP53 Mutational Status for Nonsquamous Programmed Death-Ligand 1–High (≥50%) NSCLC in the German National Network Genomic Medicine Lung Cancer. Journal of Thoracic Oncology (2024). doi: 10.1016/j.jtho.2023.12.015.Li Y, Ma M, Wang X, Li J, Fang Z, Li J, Yang B, Lu Y, Xu X, Li Y. Celecoxib alleviates the DSS-induced ulcerative colitis in mice by enhancing intestinal barrier function, inhibiting ferroptosis and suppressing apoptosis. Immunopharmacology and Immunotoxicology (2024). doi: 10.1080/08923973.2023.2300508.Stratmann JA, Althoff FC, Doebel P, Rauh J, Trummer A, Hünerlitürkoglu AN, Frost N, Yildirim H, Christopoulos P, Burkhard O, Büschenfelde CMZ, Becker von Rose A, Alt J, Aries SP, Webendörfer M, Kaldune S, Uhlenbruch M, Tritchkova G, Waller CF, Rittmeyer A, Hoffknecht P, Braess J, Kopp HG, Grohé C, Schäfer M, Schumann C, Griesinger F, Kuon J, Sebastian M, Reinmuth N. Sotorasib in KRAS G12C-mutated non-small cell lung cancer: A multicenter real-world experience from the compassionate use program in Germany. European Journal of Cancer 201 (2024). doi: 10.1016/j.ejca.2024.113911.Ahmad M, Haffner-Luntzer M, Schoppa A, Najafova Z, Lukic T, Yorgan TA, Amling M, Schinke T, Ignatius A. Mechanical induction of osteoanabolic Wnt1 promotes osteoblast differentiation via Plat. FASEB Journal 38(4) (2024). doi: 10.1096/fj.202301424RR.Charpidou A, Gerotziafas G, Popat S, Araujo A, Scherpereel A, Kopp H, Bironzo P, Massard G, Jiménez D, Falanga A, Kollias A, Syrigos K. Lung Cancer Related Thrombosis (LCART): Focus on Immune Checkpoint Blockade. Cancers 16(2) (2024). doi: 10.3390/cancers16020450.Bamidele AO, Mishra SK, Piovezani Ramos G, Hirsova P, Klatt EE, Abdelrahman LM, Sagstetter MR, Davidson HM, Fehrenbach PJ, Valenzuela-Pérez L, Kim Lee HS, Zhang S, Aguirre Lopez A, Kurdi AT, Westphal MS, Gonzalez MM, Gaballa JM, Kosinsky RL, Lee HE, Smyrk TC, Bantug G, Gades NM, Faubion WA. Interleukin 21 Drives a Hypermetabolic State and CD4+ T-Cell-Associated Pathogenicity in Chronic Intestinal Inflammation. Gastroenterology (2024). doi: 10.1053/j.gastro.2024.01.026.Saul D, Doolittle ML, Rowsey JL, Froemming MN, Kosinsky RL, Vos SJ, Ruan M, LeBrasseur N, Chandra A, Pignolo R, Passos JF, Farr JN, Monroe DG, Khosla S. Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair. bioRxiv : the preprint server for biology (2024). doi: 10.1101/2024.02.01.578420.Prokakis E, Bamahmoud H, Jansari S, Fritsche L, Dietz A, Boshnakovska A, Rehling P, Johnsen SA, Gallwas J, Wegwitz F. USP22 supports the aggressive behavior of basal-like breast cancer by stimulating cellular respiration. Cell Communication and Signaling 22(1) (2024). doi: 10.1186/s12964-023-01441-5. 2023Farr JN, Saul D, Doolittle ML, Kaur J, Rowsey JL, Vos SJ, Froemming MN, Lagnado AB, Zhu Y, Weivoda M, Ikeno Y, Pignolo RJ, Niedernhofer LJ, Robbins PD, Jurk D, Passos JF, LeBrasseur NK, Tchkonia T, Kirkland JL, Monroe DG, Khosla S. Local senolysis in aged mice only partially replicates the benefits of systemic senolysis. Journal of Clinical Investigation 133(8) (2023). doi: 10.1172/JCI162519.Samakkarnthai P, Saul D, Zhang L, Aversa Z, Doolittle ML, Sfeir JG, Kaur J, Atkinson EJ, Edwards JR, Russell GG, Pignolo RJ, Kirkland JL, Tchkonia T, Niedernhofer LJ, Monroe DG, Lebrasseur NK, Farr JN, Robbins PD, Khosla S. In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers. Aging 15(9), 3331-3355 (2023). doi: 10.18632/aging.204701.Doolittle ML, Saul D, Kaur J, Rowsey JL, Vos SJ, Pavelko KD, Farr JN, Monroe DG, Khosla S. Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton. Nature Communications 14(1), 4587-4587 (2023). doi: 10.1038/s41467-023-40393-9.Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF. Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature 622(7983), 627-636 (2023). doi: 10.1038/s41586-023-06621-4.Steinlein S, Essmann F, Ghilardi AF, Horn H, Schüler J, Hausser A, Sun L, Ott G, Kalla C. Indolyl-chalcone derivatives trigger apoptosis in cisplatin-resistant mesothelioma cells through aberrant tubulin polymerization and deregulation of microtubule-associated proteins. Frontiers in Oncology 13 (2023). doi: 10.3389/FONC.2023.1190988.Roggia C, Armeanu-Ebinger S, Gschwind A, Seibel-Kelemen O, Hertler S, Faust U, Liebmann A, Haack TB, Neumann M, Bonzheim I, Forschner A, Kopp HG, Herster F, Hartkopf A, Bitzer M, Malek NP, Brecht IB, Ruhm K, Möller Y, Löwenheim H, Ossowski S, Rieß OH, Schroeder C. Germline findings in patients with advanced malignancies screened with paired blood–tumour testing for personalised treatment approaches. European Journal of Cancer 179, 48-55 (2023). doi: 10.1016/j.ejca.2022.11.003.Li Y, Xu X, Wang X, Zhang C, Hu A, Li Y. MGST1 Expression Is Associated with Poor Prognosis, Enhancing the Wnt/β-Catenin Pathway via Regulating AKT and Inhibiting Ferroptosis in Gastric Cancer. ACS omega 8(26), 23683-23694 (2023). doi: 10.1021/acsomega.3c01782.Goetze TO, Hofheinz RD, Gaiser T, Schmalenberg H, Strumberg D, Goekkurt E, Angermeier S, Zander T, Kopp HG, Pink D, Siegler G, Schenk M, de Vita F, Galizia G, Maiello E, Bechstein WO, Elshafei M, Loose M, Sookthai D, Brulin T, Pauligk C, Homann N, Al-Batran SE. Perioperative FLOT plus ramucirumab for resectable esophagogastric adenocarcinoma: A randomized phase II/III trial of the German AIO and Italian GOIM. International Journal of Cancer 153(1), 153-163 (2023). doi: 10.1002/ijc.34495.Ramos GP, Bamidele AO, Klatt EE, Sagstetter MR, Kurdi AT, Hamdan FH, Kosinsky RL, Gaballa JM, Nair A, Sun Z, Dasari S, Lanza IR, Rozeveld CN, Schott MB, Urrutia G, Westphal MS, Clarkson BD, Howe CL, Marietta EV, Luckey DH, Murray JA, Gonzalez M, Braga Neto MB, Gibbons HR, Smyrk TC, Johnsen S, Lomberk G, Faubion WA. G9a Modulates Lipid Metabolism in CD4 T Cells to Regulate Intestinal Inflammation. Gastroenterology 164(2), 256-271.e10 (2023). doi: 10.1053/j.gastro.2022.10.011.Hamdan FH, Abdelrahman AM, Kutschat AP, Wang X, Ekstrom TL, Jalan-Sakrikar N, Wegner Wippel C, Taheri N, Tamon L, Kopp W, Aggrey-Fynn J, Bhagwate AV, Alva-Ruiz R, Lynch I, Yonkus J, Kosinsky RL, Gaedcke J, Hahn SA, Siveke JT, Graham R, Najafova Z, Hessmann E, Truty MJ, Johnsen SA. Interactive enhancer hubs (iHUBs) mediate transcriptional reprogramming and adaptive resistance in pancreatic cancer. Gut 72(6), 1174-11185 (2023). doi: 10.1136/gutjnl-2022-328154.Wang X, Kutschat AP, Aggrey-Fynn J, Hamdan FH, Graham RP, Wixom AQ, Souto Y, Ladigan-Badura S, Yonkus JA, Abdelrahman AM, Alva-Ruiz R, Gaedcke J, Ströbel P, Kosinsky RL, Wegwitz F, Hermann P, Truty MJ, Siveke JT, Hahn SA, Hessmann E, Johnsen SA, Najafova Z. Identification of a ∆Np63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma. Molecular Cancer Research 21(9), 881-891 (2023). doi: 10.1158/1541-7786.MCR-22-0916.Hamacher R, Liu X, Schuler MK, Hentschel L, Schöffski P, Kopp HG, Bauer S, Kasper B, Lindner L, Chemnitz JM, Crysandt M, Stein A, Steffen B, Richter S, Egerer G, Ivanyi P, Kunitz A, Grünwald V. A post hoc analysis of the EPAZ trial: The role of geriatric variables in elderly soft tissue sarcoma patients on toxicity and outcome. European Journal of Cancer 181, 145-154 (2023). doi: 10.1016/j.ejca.2022.12.012.Zhang Z, Wang X, Hamdan FH, Likhobabina A, Patil S, Aperdannier L, Sen M, Traub J, Neesse A, Fischer A, Papantonis A, Singh SK, Ellenrieder V, Johnsen SA, Hessmann E. NFATc1 Is a Central Mediator of EGFR-Induced ARID1A Chromatin Dissociation During Acinar Cell Reprogramming. CMGH 15(5), 1219-1246 (2023). doi: 10.1016/j.jcmgh.2023.01.015.Saul D, Kosinsky RL. Spatial transcriptomics herald a new era of transcriptome research. Clinical and translational medicine 13(5), e1264-e1264 (2023). doi: 10.1002/ctm2.1264.Prokakis E, Jansari S, Boshnakovska A, Wiese M, Kusch K, Kramm C, Dullin C, Rehling P, Glatzel M, Pantel K, Wikman H, Johnsen SA, Gallwas J, Wegwitz F. RNF40 epigenetically modulates glycolysis to support the aggressiveness of basal-like breast cancer. Cell Death and Disease 14(9) (2023). doi: 10.1038/s41419-023-06157-5.Saul D, Jurk D, Doolittle ML, Kosinsky RL, Monroe DG, LeBrasseur NK, Robbins PD, Niedernhofer LJ, Khosla S, Passos JF. Distinct secretomes in p16- and p21- positive senescent cells across tissues. bioRxiv : the preprint server for biology (2023). doi: 10.1101/2023.12.05.569858.Zhou F, Aroua N, Liu Y, Rohde C, Cheng J, Wirth AK, Fijalkowska D, Göllner S, Lotze M, Yun H, Yu X, Pabst C, Sauer T, Oellerich T, Serve H, Röllig C, Bornhäuser M, Thiede C, Baldus C, Frye M, Raffel S, Krijgsveld J, Jeremias I, Beckmann R, Trumpp A, Müller-Tidow C. A Dynamic rRNA Ribomethylome Drives Stemness in Acute Myeloid Leukemia. Cancer Discovery 13(2), 332-347 (2023). doi: 10.1158/2159-8290.CD-22-0210.Agrawal-Singh S, Bagri J, Giotopoulos G, Azazi DMA, Horton SJ, Lopez CK, Anand S, Bach AS, Stedham F, Antrobus R, Houghton JW, Vassiliou GS, Sasca D, Yun H, Whetton AD, Huntly BJP. HOXA9 forms a repressive complex with nuclear matrix–associated protein SAFB to maintain acute myeloid leukemia. Blood 141(14), 1737-1754 (2023). doi: 10.1182/blood.2022016528. 2022Saul D, Khosla S. Fracture Healing in the Setting of Endocrine Diseases, Aging, and Cellular Senescence. Endocrine Reviews 43(6), 984-1002 (2022). doi: 10.1210/endrev/bnac008.Saul D, Kosinsky RL, Atkinson EJ, Doolittle ML, Zhang X, LeBrasseur NK, Pignolo RJ, Robbins PD, Niedernhofer LJ, Ikeno Y, Jurk D, Passos JF, Hickson LJ, Xue A, Monroe DG, Tchkonia T, Kirkland JL, Farr JN, Khosla S. A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues. Nature Communications 13(1), 4827-4827 (2022). doi: 10.1038/s41467-022-32552-1.Mangiapane LR, Nicotra A, Turdo A, Gaggianesi M, Bianca P, Di Franco S, Sardina DS, Veschi V, Signore M, Beyes S, Fagnocchi L, Fiori ME, Bongiorno MR, Lo Iacono M, Pillitteri I, Ganduscio G, Gulotta G, Medema JP, Zippo A, Todaro M, De Maria R, Stassi G. PI3K-driven HER2 expression is a potential therapeutic target in colorectal cancer stem cells. Gut 71(1), 119-128 (2022). doi: 10.1136/gutjnl-2020-323553.Turdo A, Gaggianesi M, Di Franco S, Veschi V, D’Accardo C, Porcelli G, Lo Iacono M, Pillitteri I, Verona F, Militello G, Zippo A, Poli V, Fagnocchi L, Beyes S, Stella S, Lattanzio R, Faldetta N, Lentini VL, Porcasi R, Pistone G, Bongiorno MR, Stassi G, De Maria R, Todaro M. Effective targeting of breast cancer stem cells by combined inhibition of Sam68 and Rad51. 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Oncotarget 7(21), 30396-30407 (2016). doi: 10.18632/ONCOTARGET.8878.Wiese M, Schill F, Sturm D, Pfister S, Hulleman E, Johnsen SA, Kramm CM. No Significant Cytotoxic Effect of the EZH2 Inhibitor Tazemetostat (EPZ-6438) on Pediatric Glioma Cells with Wildtype Histone 3 or Mutated Histone 3.3. Klinische Padiatrie 228(3), 113-117 (2016). doi: 10.1055/S-0042-105292.Wienken M, Dickmanns A, Nemajerova A, Kramer D, Najafova Z, Weiss M, Karpiuk O, Kassem M, Zhang Y, Lozano G, Johnsen SA, Moll UM, Zhang X, Dobbelstein M. MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53. Molecular Cell 61(1), 68-83 (2016). doi: 10.1016/J.MOLCEL.2015.12.008.Hossan T, Nagarajan S, Baumgart SJ, Xie W, Magallanes RT, Hernandez C, Chiaroni PM, Indenbirken D, Spitzner M, Thomas-Chollier M, Grade M, Thieffry D, Grundhoff A, Wegwitz F, Johnsen SA. Histone Chaperone SSRP1 is Essential for Wnt Signaling Pathway Activity During Osteoblast Differentiation. Stem Cells 34(5), 1369-1376 (2016). doi: 10.1002/STEM.2287.Sriraman A, Radovanovic M, Wienken M, Najafova Z, Li Y, Dobbelstein M. Cooperation of Nutlin-3a and a Wip1 inhibitor to induce p53 activity. Oncotarget 7(22), 31623-31638 (2016). doi: 10.18632/oncotarget.9302. 2015Sharma A, Yun H, Jyotsana N, Chaturvedi A, Schwarzer A, Yung E, Lai CK, Kuchenbauer F, Argiropoulos B, Görlich K, Ganser A, Humphries RK, Heuser M. Constitutive IRF8 expression inhibits AML by activation of repressed immune response signaling. Leukemia 29(1), 157-168 (2015). doi: 10.1038/leu.2014.162.Dannenmann B, Lehle S, Hildebrand DG, Kübler A, Grondona P, Schmid V, Holzer K, Fröschl M, Essmann F, Rothfuss O, Schulze-Osthoff K. High glutathione and glutathione peroxidase-2 levels mediate cell-type-specific DNA damage protection in human induced pluripotent stem cells. Stem Cell Reports 4(5), 886-898 (2015). doi: 10.1016/J.STEMCR.2015.04.004.Kosinsky RL, Wegwitz F, Hellbach N, Dobbelstein M, Mansouri A, Vogel T, Begus-Nahrmann Y, Johnsen SA. Usp22 deficiency impairs intestinal epithelial lineage specification in vivo. Oncotarget 6(35), 37906-37918 (2015). doi: 10.18632/oncotarget.5412.Benito E, Urbanke H, Ramachandran B, Barth J, Halder R, Awasthi A, Jain G, Capece V, Burkhardt S, Navarro-Sala M, Nagarajan S, Schötz AL, Johnsen SA, Bonn S, Löhrmann R, Dean C, Fischer A. HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models. Journal of Clinical Investigation 125(9), 3572-3584 (2015). doi: 10.1172/JCI79942.Werner S, Brors B, Eick J, Marques E, Pogenberg V, Parret A, Kemming D, Wood AW, Edgren H, Neubauer H, Streichert T, Riethdorf S, Bedi U, Baccelli I, Jucker M, Eils R, Fehm T, Trumpp A, Johnsen SA, Klefstrom J, Wilmanns M, Muller V, Pantel K, Wikman H. Suppression of early hematogenous dissemination of human breast cancer cells to bone marrow by retinoic acid–induced 2. Cancer Discovery 5(5), 506-519 (2015). doi: 10.1158/2159-8290.CD-14-1042.Chen NM, Singh G, Koenig A, Liou GY, Storz P, Zhang JS, Regul L, Nagarajan S, Kühnemuth B, Johnsen SA, Hebrok M, Siveke J, Billadeau DD, Ellenrieder V, Hessmann E. NFATc1 links EGFR signaling to induction of sox9 transcription and acinar-ductal transdifferentiation in the pancreas. Gastroenterology 148(5), 1024-1034.e9 (2015). doi: 10.1053/J.GASTRO.2015.01.033.Nagarajan S, Benito E, Fischer A, Johnsen SA. H4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription. Oncotarget 6(9), 7305-7317 (2015). doi: 10.18632/ONCOTARGET.3439.Schmidt JM, Panzilius E, Bartsch HS, Irmler M, Beckers J, Kari V, Linnemann JR, Dragoi D, Hirschi B, Kloos UJ, Sass S, Theis F, Kahlert S, Johnsen SA, Sotlar K, Scheel CH. Stem-cell-like properties and epithelial plasticity arise as stable traits after transient twist1 activation. Cell Reports 10(2), 131-139 (2015). doi: 10.1016/J.CELREP.2014.12.032.Bedi U, Scheel AH, Hennion M, Begus-Nahrmann Y, Rüschoff J, Johnsen SA. SUPT6H controls estrogen receptor activity and cellular differentiation by multiple epigenomic mechanisms. Oncogene 34(4), 465-473 (2015). doi: 10.1038/ONC.2013.558.Nitzki F, Tolosa EJ, Cuvelier N, Frommhold A, Salinas-Riester G, Johnsen SA, Fernandez-Zapico ME, Hahn H. Overexpression of mutant Ptch in rhabdomyosarcomas is associated with promoter hypomethylation and increased Gli1 and H3K4me3 occupancy. Oncotarget 6(11), 9113-9124 (2015). doi: 10.18632/ONCOTARGET.3272. 2014Möller Y, Siegemund M, Beyes S, Herr R, Lecis D, Delia D, Kontermann R, Brummer T, Pfizenmaier K, Olayioye MA. EGFR-Targeted TRAIL and a Smac Mimetic Synergize to Overcome Apoptosis Resistance in KRAS Mutant Colorectal Cancer Cells. PLoS ONE 9(9), e107165-e107165 (2014). doi: 10.1371/journal.pone.0107165.Feil S, Fehrenbacher B, Lukowski R, Essmann F, Schulze-Osthoff K, Schaller M, Feil R. Transdifferentiation of vascular smooth muscle cells to macrophage-like cells during atherogenesis. Circulation Research 115(7), 662-667 (2014). doi: 10.1161/CIRCRESAHA.115.304634.Weiland T, Lampe J, Essmann F, Venturelli S, Berger A, Bossow S, Berchtold S, Schulze-Osthoff K, Lauer UM, Bitzer M. Enhanced killing of therapy-induced senescent tumor cells by oncolytic measles vaccine viruses. International Journal of Cancer 134(1), 235-243 (2014). doi: 10.1002/IJC.28350.Lehle S, Hildebrand DG, Merz B, Malak PN, Becker MS, Schmezer P, Essmann F, Schulze-Osthoff K, Rothfuss O. LORD-Q: A long-run real-time PCR-based DNA-damage quantification method for nuclear and mitochondrial genome analysis. Nucleic Acids Research 42(6) (2014). doi: 10.1093/NAR/GKT1349.Yun H, Damm F, Yap D, Schwarzer A, Chaturvedi A, Jyotsana N, Lübbert M, Bullinger L, Döhner K, Geffers R, Aparicio S, Humphries RK, Ganser A, Heuser M. Impact of MLL5 expression on decitabine efficacy and DNA methylation in acute myeloid leukemia. Haematologica 99(9), 1456-1464 (2014). doi: 10.3324/haematol.2013.101386.Heuser M, Schlarmann C, Dobbernack V, Panagiota V, Wiehlmann L, Walter C, Beier F, Ziegler P, Yun H, Kade S, Kirchner A, Huang L, Koenecke C, Eder M, Brümmendorf TH, Dugas M, Ganser A, Thol F. Genetic characterization of acquired aplastic anemia by targeted sequencing. Haematologica 99(9) (2014). doi: 10.3324/haematol.2013.101642.Bedi U, Mishra VK, Wasilewski D, Scheel C, Johnsen SA. Epigenetic plasticity: A central regulator of epithelial-tomesenchymal transition in cancer. Oncotarget 5(8), 2016-2029 (2014). doi: 10.18632/ONCOTARGET.1875.Gaedcke J, Leha A, Claus R, Weichenhan D, Jung K, Kitz J, Grade M, Wolff HA, Jo P, Doyen J, Gérard JP, Johnsen SA, Plass C, Beißbarth T, Ghadimi M. Identification of a DNA methylation signature to predict disease-free survival in locally advanced rectal cancer. Oncotarget 5(18), 8123-8135 (2014). doi: 10.18632/ONCOTARGET.2347.Nagarajan S, Hossan T, Alawi M, Najafova Z, Indenbirken D, Bedi U, Taipaleenmäki H, Ben-Batalla I, Scheller M, Loges S, Knapp S, Hesse E, Chiang CM, Grundhoff A, Johnsen SA. Bromodomain Protein BRD4 Is Required for Estrogen Receptor-Dependent Enhancer Activation and Gene Transcription. Cell Reports 8(2), 460-469 (2014). doi: 10.1016/J.CELREP.2014.06.016.Mishra VK, Johnsen SA. Targeted therapy of epigenomic regulatory mechanisms controlling the epithelial to mesenchymal transition during tumor progression. Cell and Tissue Research 356(3), 617-630 (2014). doi: 10.1007/S00441-014-1912-Y. 2013Keil E, Höcker R, Schuster M, Essmann F, Ueffing N, Hoffman B, Liebermann DA, Pfeffer K, Schulze-Osthoff K, Schmitz I. Phosphorylation of Atg5 by the Gadd45β-MEKK4-p38 pathway inhibits autophagy. Cell Death and Differentiation 20(2), 321-332 (2013). doi: 10.1038/CDD.2012.129.Bareiss PM, Paczulla A, Wang H, Schairer R, Wiehr S, Kohlhofer U, Rothfuss OC, Fischer A, Perner S, Staebler A, Wallwiener D, Fend F, Fehm T, Pichler B, Kanz L, Quintanilla-Martinez L, Schulze-Osthoff K, Essmann F, Lengerke C. SOX2 expression associates with stem cell state in human ovarian carcinoma. Cancer Research 73(17), 5544-5555 (2013). doi: 10.1158/0008-5472.CAN-12-4177.Hildebrand DG, Alexander E, Hörber S, Lehle S, Obermayer K, Münck N, Rothfuss O, Frick J, Morimatsu M, Schmitz I, Roth J, Ehrchen JM, Essmann F, Schulze-Osthoff K. IκBζ Is a Transcriptional Key Regulator of CCL2/MCP-1. The Journal of Immunology 190(9), 4812-4820 (2013). doi: 10.4049/JIMMUNOL.1300089.Alexander E, Hildebrand DG, Kriebs A, Obermayer K, Manz M, Rothfuss O, Schulze-Osthoff K, Essmann F. IκBζ is a regulator of the senescence-associated secretory phenotype in DNA damage- and oncogene-induced senescence. Journal of Cell Science 126(16), 3738-3745 (2013). doi: 10.1242/JCS.128835.Braumüller H, Wieder T, Brenner E, Aßmann S, Hahn M, Alkhaled M, Schilbach K, Essmann F, Kneilling M, Griessinger C, Ranta F, Ullrich S, Mocikat R, Braungart K, Mehra T, Fehrenbacher B, Berdel J, Niessner H, Meier F, Van Den Broek M, Häring HU, Handgretinger R, Quintanilla-Martinez L, Fend F, Pesic M, Bauer J, Zender L, Schaller M, Schulze-Osthoff K, Röcken M. T-helper-1-cell cytokines drive cancer into senescence. Nature 494(7437), 361-365 (2013). doi: 10.1038/NATURE11824.Garbers C, Kuck F, Aparicio-Siegmund S, Konzak K, Kessenbrock M, Sommerfeld A, Häussinger D, Lang PA, Brenner D, Mak TW, Rose-John S, Essmann F, Schulze-Osthoff K, Piekorz RP, Scheller J. Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR). Cell Cycle 12(21), 3421-3432 (2013). doi: 10.4161/CC.26431.Venturelli S, Berger A, Weiland T, Essmann F, Waibel M, Nuebling T, Häcker S, Schenk M, Schulze-Osthoff K, Salih HR, Fulda S, Sipos B, Johnstone RW, Lauer UM, Bitzer M. Differential induction of apoptosis and senescence by the DNA methyltransferase inhibitors 5-azacytidine and 5-aza-20-deoxycytidine in solid tumor cells. Molecular Cancer Therapeutics 12(10), 2226-2236 (2013). doi: 10.1158/1535-7163.MCT-13-0137.Gillissen B, Richter A, Richter A, Overkamp T, Essmann F, Hemmati PG, Preissner R, Belka C, Daniel PT. Targeted therapy of the XIAP/proteasome pathway overcomes TRAIL-resistance in carcinoma by switching apoptosis signaling to a Bax/Bak-independent 'type I' mode. Cell Death and Disease 4(5) (2013). doi: 10.1038/CDDIS.2013.67.Hildebrand DG, Lehle S, Borst A, Haferkamp S, Essmann F, Schulze-Osthoff K. α-Fucosidase as a novel convenient biomarker for cellular senescence. Cell Cycle 12(12), 1922-1927 (2013). doi: 10.4161/CC.24944.Konantz M, André MC, Ebinger M, Grauer M, Wang H, Grzywna S, Rothfuss OC, Lehle S, Kustikova OS, Salih HR, Handgretinger R, Fend F, Baum C, Kanz L, Quintanilla-Martinez L, Schulze-Osthoff K, Essmann F, Lengerke C. EVI-1 modulates leukemogenic potential and apoptosis sensitivity in human acute lymphoblastic leukemia. Leukemia 27(1), 56-65 (2013). doi: 10.1038/LEU.2012.211.Dietrich D, Seiler F, Essmann F, Dodt G. Identification of the kinesin KifC3 as a new player for positioning of peroxisomes and other organelles in mammalian cells. Biochimica et Biophysica Acta - Molecular Cell Research 1833(12), 3013-3024 (2013). doi: 10.1016/J.BBAMCR.2013.08.002.Chaturvedi A, Araujo Cruz MM, Jyotsana N, Sharma A, Yun H, Görlich K, Wichmann M, Schwarzer A, Preller M, Thol F, Meyer J, Haemmerle R, Struys EA, Jansen EE, Modlich U, Li Z, Sly LM, Geffers R, Lindner R, Manstein DJ, Lehmann U, Krauter J, Ganser A, Heuser M. Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML. Blood 122(16), 2877-2887 (2013). doi: 10.1182/blood-2013-03-491571.Serebryanskaya TV, Yung T, Bogdanov AA, Shchebet A, Johnsen SA, Lyakhov AS, Ivashkevich LS, Ibrahimava ZA, Garbuzenco TS, Kolesnikova TS, Melnova NI, Gaponik PN, Ivashkevich OA. Synthesis, characterization, and biological evaluation of new tetrazole-based platinum(II) and palladium(II) chlorido complexes - Potent cisplatin analogues and their trans isomers. Journal of Inorganic Biochemistry 120, 44-53 (2013). doi: 10.1016/J.JINORGBIO.2012.12.001.Kari V, Karpiuk O, Tieg B, Kriegs M, Dikomey E, Krebber H, Begus-Nahrmann Y, Johnsen SA. A Subset of Histone H2B Genes Produces Polyadenylated mRNAs under a Variety of Cellular Conditions. PLoS ONE 8(5) (2013). doi: 10.1371/JOURNAL.PONE.0063745.Zhang H, Park SH, Pantazides BG, Karpiuk O, Warren MD, Hardy CW, Duong DM, Park SJ, Kim HS, Vassilopoulos A, Seyfried NT, Johnsen SA, Gius D, Yu DS. SIRT2 directs the replication stress response through CDK9 deacetylation. Proceedings of the National Academy of Sciences of the United States of America 110(33), 13546-13551 (2013). doi: 10.1073/PNAS.1301463110.Jiao B, Taniguchi-Ishigaki N, Güngör C, Peters MA, Chen YW, Riethdorf S, Drung A, Ahronian LG, Shin J, Pagnis R, Pantel K, Tachibana T, Lewis BC, Johnsen SA, Bach I. Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleocytoplasmic shuttling. Molecular Biology of the Cell 24(19), 3085-3096 (2013). doi: 10.1091/MBC.E13-05-0239. 2012Essmann F, Schulze-Osthoff K. Translational approaches targeting the p53 pathway for anti-cancer therapy. British Journal of Pharmacology 165(2), 328-344 (2012). doi: 10.1111/J.1476-5381.2011.01570.X.Trivigno D, Essmann F, Huber SM, Rudner J. Deubiquitinase USP9x confers radioresistance through stabilization of Mcl-1. Neoplasia (United States) 14(10), 893-904 (2012). doi: 10.1593/NEO.12598.Weiland T, Berger A, Essmann F, Lauer UM, Bitzer M, Venturelli S. Kinetic tracking of therapy-induced senescence using the real-time cell analyzer single plate system. Assay and Drug Development Technologies 10(3), 289-295 (2012). doi: 10.1089/ADT.2011.0402.Damm F, Wagner K, Görlich K, Morgan M, Thol F, Yun H, Delwel R, Valk PJM, Löwenberg B, Heuser M, Ganser A, Krauter J. ID1 expression associates with other molecular markers and is not an independent prognostic factor in cytogenetically normal acute myeloid leukaemia. British Journal of Haematology 158(2), 208-215 (2012). doi: 10.1111/j.1365-2141.2012.09144.x.Thol F, Yun H, Sonntag A, Damm F, Weissinger EM, Krauter J, Wagner K, Morgan M, Wichmann M, Göhring G, Bug G, Ottmann O, Hofmann W, Schambach A, Schlegelberger B, Haferlach T, Bowen D, Mills K, Ganser A, Heuser M. Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes. Annals of hematology 91(8), 1221-1233 (2012). doi: 10.1007/s00277-012-1457-7.Siebel JF, Kosinsky RL, Åkerström B, Knipp M. Insertion of Heme b into the Structure of the Cys34-Carbamidomethylated Human Lipocalin α 1-Microglobulin: Formation of a [(Heme) 2(α 1-Microglobulin)] 3 Complex. ChemBioChem 13(6), 879-887 (2012). doi: 10.1002/cbic.201100808.Shchebet A, Karpiuk O, Kremmer E, Eick D, Johnsen SA. Phosphorylation by cyclin-dependent kinase-9 controls ubiquitin-conjugating enzyme-2A function. Cell Cycle 11(11), 2122-2127 (2012). doi: 10.4161/CC.20548.Johnsen SA. The enigmatic role of H2Bub1 in cancer. FEBS Letters 586(11), 1592-1601 (2012). doi: 10.1016/J.FEBSLET.2012.04.002.Prenzel T, Kramer F, Bedi U, Nagarajan S, Beissbarth T, Johnsen SA. Cohesin is required for expression of the estrogen receptor-alpha (ESR1) gene. Epigenetics and Chromatin 5(1) (2012). doi: 10.1186/1756-8935-5-13.Karpiuk O, Najafova Z, Kramer F, Hennion M, Galonska C, König A, Snaidero N, Vogel T, Shchebet A, Begus-Nahrmann Y, Kassem M, Simons M, Shcherbata H, Beissbarth T, Johnsen SA. The Histone H2B Monoubiquitination Regulatory Pathway Is Required for Differentiation of Multipotent Stem Cells. Molecular Cell 46(5), 705-713 (2012). doi: 10.1016/J.MOLCEL.2012.05.022.Johnsen SA. CDK9 and H2B Monoubiquitination: A Well-Choreographed Dance. PLoS Genetics 8(8) (2012). doi: 10.1371/JOURNAL.PGEN.1002860. 2011Graupner V, Alexander E, Overkamp T, Rothfuss O, De Laurenzi V, Gillissen BF, Daniel PT, Schulze-Osthoff K, Essmann F. Differential regulation of the proapoptotic multidomain protein Bak by p53 and p73 at the promoter level. Cell Death and Differentiation 18(7), 1130-1139 (2011). doi: 10.1038/CDD.2010.179.Heuser M, Yun H, Berg T, Yung E, Argiropoulos B, Kuchenbauer F, Park G, Hamwi I, Palmqvist L, Lai CK, Leung M, Lin G, Chaturvedi A, Thakur BK, Iwasaki M, Bilenky M, Thiessen N, Robertson G, Hirst M, Kent D, Wilson NK, Göttgens B, Eaves C, Cleary ML, Marra M, Ganser A, Humphries RK. Cell of Origin in AML: Susceptibility to MN1-Induced Transformation Is Regulated by the MEIS1/AbdB-like HOX Protein Complex. Cancer Cell 20(1), 39-52 (2011). doi: 10.1016/j.ccr.2011.06.020.Thol F, Damm F, Lüdeking A, Winschel C, Wagner K, Morgan M, Yun H, Göhring G, Schlegelberger B, Hoelzer D, Lübbert M, Kanz L, Fiedler W, Kirchner H, Heil G, Krauter J, Ganser A, Heuser M. Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia. Journal of Clinical Oncology 29(21), 2889-2896 (2011). doi: 10.1200/JCO.2011.35.4894.Thol F, Friesen I, Damm F, Yun H, Weissinger EM, Krauter J, Wagner K, Chaturvedi A, Sharma A, Wichmann M, Göhring G, Schumann C, Bug G, Ottmann O, Hofmann WK, Schlegelberger B, Heuser M, Ganser A. Prognostic significance of ASXL1 mutations in patients with myelodysplastic syndromes. Journal of Clinical Oncology 29(18), 2499-2506 (2011). doi: 10.1200/JCO.2010.33.4938.Shi JY, Ren ZH, Jiao B, Xiao R, Yun HY, Chen B, Zhao WL, Zhu Q, Chen Z, Chen SJ. Genetic variations of DNA repair genes and their prognostic significance in patients with acute myeloid leukemia. International Journal of Cancer 128(1), 233-238 (2011). doi: 10.1002/ijc.25318.Thol F, Winschel C, Lüdeking A, Yun H, Friesen I, Damm F, Wagner K, Krauter J, Heuser M, Ganser A. Rare occurrence of DNMT3A mutations in myelodysplastic syndromes. Haematologica 96(12), 1870-1873 (2011). doi: 10.3324/haematol.2011.045559.Kari V, Shchebet A, Neumann H, Johnsen SA. The H2B ubiquitin ligase RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair. Cell Cycle 10(20), 3495-3504 (2011). doi: 10.4161/CC.10.20.17769.Prenzel T, Begus-Nahrmann Y, Kramer F, Hennion M, Hsu C, Gorsler T, Hintermair C, Eick D, Kremmer E, Simons M, Beissbarth T, Johnsen SA. Estrogen-dependent gene transcription in human breast cancer cells relies upon proteasome-dependent monoubiquitination of histone H2B. Cancer Research 71(17), 5739-5753 (2011). doi: 10.1158/0008-5472.CAN-11-1896. 2010Tenenbaum T, Schwerk C, Rybarczyk K, Essmann F, Seibt A, Mlleken ML, Zeni P, Schroten H. TNF induces choroid plexus epithelial cell barrier alterations by apoptotic and nonapoptotic mechanisms. Journal of Biomedicine and Biotechnology 2010 (2010). doi: 10.1155/2010/307231.Schmidt S, Schneider L, Essmann F, Cirstea IC, Kuck F, Kletke A, Jänicke RU, Wiek C, Hanenberg H, Ahmadian MR, Schulze-Osthoff K, Nürnberg B, Piekorz RP. The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program. Oncogene 29(46), 6184-6192 (2010). doi: 10.1038/ONC.2010.354.Baygi ME, Soheili ZS, Essmann F, Deezagi A, Engers R, Goering W, Schulz WA. Slug/SNAI2 regulates cell proliferation and invasiveness of metastatic prostate cancer cell lines. Tumor Biology 31(4), 297-307 (2010). doi: 10.1007/S13277-010-0037-5.Schmidt S, Essmann F, Cirstea IC, Kuck F, Thakur HC, Singh M, Kletke A, Jänicke RU, Wiek C, Hanenberg H, Ahmadian MR, Schulze-Osthoff K, Nürnberg B, Piekorz RP. The centrosome and mitotic spindle apparatus in cancer and senescence. Cell Cycle 9(22), 4469-4473 (2010). doi: 10.4161/CC.9.22.13684.Cetindere T, Nambiar S, Santourlidis S, Essmann F, Hassan M. Induction of indoleamine 2, 3-dioxygenase by death receptor activation contributes to apoptosis of melanoma cells via mitochondrial damage-dependent ROS accumulation. Cellular Signalling 22(2), 197-211 (2010). doi: 10.1016/J.CELLSIG.2009.09.013.Damm F, Heuser M, Morgan M, Yun H, Großhennig A, Göhring G, Schlegelberger B, Döhner K, Ottmann O, Lübbert M, Heit W, Kanz L, Schlimok G, Raghavachar A, Fiedler W, Kirchner H, Döhner H, Heil G, Ganser A, Krauter J. Single nucleotide polymorphism in the mutational hotspot of WT1 predicts a favorable outcome in patients with cytogenetically normal acute myeloid leukemia. Journal of Clinical Oncology 28(4), 578-585 (2010). doi: 10.1200/JCO.2009.23.0342.Pirngruber J, Johnsen SA. Induced G1 cell-cycle arrest controls replication-dependent histone mRNA 3′ end processing through p21, NPAT and CDK9. Oncogene 29(19), 2853-2863 (2010). doi: 10.1038/ONC.2010.42.Büttner N, Johnsen SA, Kügler S, Vogel T. Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex. Proceedings of the National Academy of Sciences of the United States of America 107(15), 7042-7047 (2010). doi: 10.1073/PNAS.0912041107.Haenssle HA, Korpas B, Hansen-Hagge C, Buhl T, Kaune KM, Johnsen S, Rosenberger A, Schön MP, Emmert S. Selection of patients for long-term surveillance with digital dermoscopy by assessment of melanoma risk factors. Archives of Dermatology 146(3), 257-264 (2010). doi: 10.1001/ARCHDERMATOL.2009.370. 2009Los M, Panigrahi S, Rashedi I, Mandal S, Stetefeld J, Essmann F, Schulze-Osthoff K. Apoptin, a tumor-selective killer. Biochimica et Biophysica Acta - Molecular Cell Research 1793(8), 1335-1342 (2009). doi: 10.1016/J.BBAMCR.2009.04.002.Werdehausen R, Fazeli S, Braun S, Hermanns H, Essmann F, Hollmann MW, Bauer I, Stevens MF. Apoptosis induction by different local anaesthetics in a neuroblastoma cell line. British Journal of Anaesthesia 103(5), 711-718 (2009). doi: 10.1093/BJA/AEP236.Graupner V, Schulze-Osthoff K, Essmann F, Jänicke RU. Functional characterization of p53β and p53γ, two isoforms of the tumor suppressor p53. Cell Cycle 8(8), 1238-1248 (2009). doi: 10.4161/CC.8.8.8251.Sohn D, Graupner V, Neise D, Essmann F, Schulze-Osthoff K, Jänicke RU. Pifithrin-α protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53. Cell Death and Differentiation 16(6), 869-878 (2009). doi: 10.1038/CDD.2009.17.Jänicke RU, Graupner V, Budach W, Essmann F. The dos and donts of p53 isoforms. Biological Chemistry 390(10), 951-963 (2009). doi: 10.1515/BC.2009.093.Rosa ID, Goffart S, Wurm M, Wiek C, Essmann F, Sobek S, Schroeder P, Zhang H, Krutmann J, Hanenberg H, Schulze-Osthoff K, Mielke C, Pommier Y, Boege F, Christensen MO. Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA. Nucleic Acids Research 37(19), 6414-6428 (2009). doi: 10.1093/NAR/GKP708.Ecke I, Petry F, Rosenberger A, Tauber S, Mönkemeyer S, Hess I, Dullin C, Kimmina S, Pirngruber J, Johnsen SA, Uhmann A, Nitzki F, Wojnowski L, Schulz-Schaeffer W, Witt O, Hahn H. Antitumor effects of a combined 5-aza-2′deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice. Cancer Research 69(3), 887-895 (2009). doi: 10.1158/0008-5472.CAN-08-0946.Pirngruber J, Shchebet A, Schreiber L, Shema E, Minsky N, Chapman RD, Eick D, Aylon Y, Oren M, Johnsen SA. CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3′-end processing. EMBO Reports 10(8), 894-900 (2009). doi: 10.1038/EMBOR.2009.108.Pirngruber J, Shchebet A, Johnsen SA. Insights into the function of the human P-TEFb component CDK9 in the regulation of chromatin modifications and co-transcriptional mRNA processing. Cell Cycle 8(22), 3636-3642 (2009). doi: 10.4161/CC.8.22.9890.Johnsen SA, Güngör C, Prenzel T, Riethdorf S, Riethdorf L, Taniguchi-Ishigaki N, Rau T, Tursun B, Furlow JD, Sauter G, Scheffner M, Pantel K, Gannon F, Bach I. Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer. Cancer Research 69(1), 128-136 (2009). doi: 10.1158/0008-5472.CAN-08-1630. 2008Pan Q, Zhu Y, Gu B, Cai X, Bai X, Yun H, Zhu J, Chen B, Weng L, Chen Z, Xue Y, Chen S. A new fusion gene NUP98-IQCG identified in an acute T-lymphoid/myeloid leukemia with a t(3;11)(q29q13;p15)del(3)(q29) translocation. Oncogene 27(24), 3414-3423 (2008). doi: 10.1038/sj.onc.1210999.Fitzner N, Clauberg S, Essmann F, Liebmann J, Kolb-Bachofen V. Human skin endothelial cells can express all 10 TLR genes and respond to respective ligands. Clinical and Vaccine Immunology 15(1), 138-146 (2008). doi: 10.1128/CVI.00257-07.Schneider L, Essmann F, Kletke A, Rio P, Hanenberg H, Schulze-Osthoff K, Nürnberg B, Piekorz RP. TACC3 depletion sensitizes to paclitaxel-induced cell death and overrides p21WAF-mediated cell cycle arrest. Oncogene 27(1), 116-125 (2008). doi: 10.1038/SJ.ONC.1210628.Hassan M, Alaoui A, Feyen O, Mirmohammadsadegh A, Essmann F, Tannapfel A, Gulbins E, Schulze-Osthoff K, Hengge UR. The BH3-only member Noxa causes apoptosis in melanoma cells by multiple pathways. Oncogene 27(33), 4557-4568 (2008). doi: 10.1038/ONC.2008.90.Neise D, Graupner V, Gillissen BF, Daniel PT, Schulze-Osthoff K, Jänicke RU, Essmann F. Activation of the mitochondrial death pathway is commonly mediated by a preferential engagement of Bak. Oncogene 27(10), 1387-1396 (2008). doi: 10.1038/SJ.ONC.1210773.Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y, Y-arden Y, Johnsen SA, Vojtesek B, Berger SL, Oren M. The histone H2B-specific ubiquitin ligase RNF20/hBREl acts as a putative tumor suppressor through selective regulation of gene expression. Genes and Development 22(19), 2664-2676 (2008). doi: 10.1101/GAD.1703008.Waddell DS, Baehr LM, Van Den Brandt J, Johnsen SA, Reichardt HM, Furlow JD, Bodine SC. The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene. American Journal of Physiology - Endocrinology and Metabolism 295(4) (2008). doi: 10.1152/AJPENDO.00646.2007. 2007Werdehausen R, Braun S, Essmann F, Schulze-Osthoff K, Walczak H, Lipfert P, Stevens MF. Lidocaine induces apoptosis via the mitochondrial pathway independently of death receptor signaling. Anesthesiology 107(1), 136-143 (2007). doi: 10.1097/01.ANES.0000268389.39436.66.Schneider L, Essmann F, Kletke A, Rio P, Hanenberg H, Wetzel W, Schulze-Osthoff K, Nürnberg B, Piekorz RP. The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival. Journal of Biological Chemistry 282(40), 29273-29283 (2007). doi: 10.1074/JBC.M704151200.Gillissen B, Essmann F, Hemmati PG, Richter A, Richter A, Öztop I, Chinnadurai G, Dörken B, Daniel PT. Mcl-1 determines the Bax dependency of Nbk/Bik-induced apoptosis. Journal of Cell Biology 179(4), 701-715 (2007). doi: 10.1083/JCB.200703040.Jänicke RU, Sohn D, Essmann F, Schulze-Osthoff K. The multiple battles fought by anti-apoptotic p21. Cell Cycle 6(4), 407-413 (2007). doi: 10.4161/CC.6.4.3855.Subramaniam M, Hawse JR, Johnsen SA, Spelsberg TC. Role of TIEG1 in biological processes and disease states. Journal of Cellular Biochemistry 102(3), 539-548 (2007). doi: 10.1002/JCB.21492. 2006Sohn D, Totzke G, Essmann F, Schulze-Osthoff K, Levkau B, Jänicke RU. The Proteasome Is Required for Rapid Initiation of Death Receptor-Induced Apoptosis. Molecular and Cellular Biology 26(5), 1967-1978 (2006). doi: 10.1128/MCB.26.5.1967-1978.2006.Tenenbaum T, Essmann F, Adam R, Seibt A, Jänicke RU, Novotny GEK, Galla HJ, Schroten H. Cell death, caspase activation, and HMGB1 release of porcine choroid plexus epithelial cells during Streptococcus suis infection in vitro. Brain Research 1100(1), 1-12 (2006). doi: 10.1016/J.BRAINRES.2006.05.041.Totzke G, Essmann F, Pohlmann S, Lindenblatt C, Jänicke RU, Schulze-Osthoff K. A novel member of the IκB family, human IκB-ζ, inhibits transactivation of p65 and its DNA binding. Journal of Biological Chemistry 281(18), 12645-12654 (2006). doi: 10.1074/JBC.M511956200.Sohn D, Essmann F, Schulze-Osthoff K, Jänicke RU. p21 blocks irradiation-induced apoptosis downstream of mitochondria by inhibition of cyclin-dependent kinase-mediated caspase-9 activation. Cancer Research 66(23), 11254-11262 (2006). doi: 10.1158/0008-5472.CAN-06-1569.Johnsen SA, Kangaspeska S, Reid G, Gannon F. Interfering with the dynamics of estrogen receptor-regulated transcription. Ernst Schering Foundation symposium proceedings 1, 1-12 (2006). doi: 10.1007/2789_2006_013. 2005Essmann F, Pohlmann S, Gillissen B, Daniel PT, Schulze-Osthoff K, Jänicke RU. Irradiation-induced translocation of p53 to mitochondria in the absence of apoptosis. Journal of Biological Chemistry 280(44), 37169-37177 (2005). doi: 10.1074/JBC.M502052200.Scholz C, Wieder T, Starck L, Essmann F, Schulze-Osthoff K, Dörken B, Daniel PT. Arsenic trioxide triggers a regulated form of caspase-independent necrotic cell death via the mitochondrial death pathway. Oncogene 24(11), 1904-1913 (2005). doi: 10.1038/SJ.ONC.1208233.Tursun B, Schlüter A, Peters MA, Viehweger B, Ostendorff HP, Soosairajah J, Drung A, Bossenz M, Johnsen SA, Schweizer M, Bernard O, Bach I. The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones. Genes and Development 19(19), 2307-2319 (2005). doi: 10.1101/GAD.1340605.Effenberger KE, Johnsen SA, Monroe DG, Spelsberg TC, Westendorf JJ. Regulation of osteoblastic phenotype and gene expression by hop-derived phytoestrogens. Journal of Steroid Biochemistry and Molecular Biology 96(5), 387-399 (2005). doi: 10.1016/J.JSBMB.2005.04.038.Subramaniam M, Gorny G, Johnsen SA, Monroe DG, Evans GL, Fraser DG, Rickard DJ, Rasmussen K, van Deursen JMA, Turner RT, Oursler MJ, Spelsberg TC. TIEG1 Null Mouse-Derived Osteoblasts Are Defective in Mineralization and in Support of Osteoclast Differentiation In Vitro. Molecular and Cellular Biology 25(3), 1191-1199 (2005). doi: 10.1128/MCB.25.3.1191-1199.2005. 2004Schmelz K, Wieder T, Tamm I, Müller A, Essmann F, Geilen CC, Schulze-Osthoff K, Dörken B, Daniel PT. Tumor necrosis factor α sensitizes malignant cells to chemotherapeutic drugs via the mitochondrial apoptosis pathway independently of caspase-8 and NF-κB. Oncogene 23(40), 6743-6759 (2004). doi: 10.1038/SJ.ONC.1207848.Essmann F, Engels IH, Totzke G, Schulze-Osthoff K, Jänicke RU. Apoptosis resistance of MCF-7 breast carcinoma cells to ionizing radiation is independent of p53 and cell cycle control but caused by the lack of caspase-3 and a caffeine-inhibitable event. Cancer Research 64(19), 7065-7072 (2004). doi: 10.1158/0008-5472.CAN-04-1082.Johnsen SA, Subramaniam M, Effenberger KE, Spelsberg TC. The TGFβ inducible early gene plays a central role in the anti-proliferative response to TGFβ. Signal Transduction 4(1-2), 29-35 (2004). doi: 10.1002/SITA.200400032.Reinholz MM, An MW, Johnsen SA, Subramaniam M, Suman VJ, Ingle JN, Roche PC, Spelsberg TC. Differential gene expression of TGFβ inducible early gene (TIEG), Smad7, Smad2 and Bard1 in normal and malignant breast tissue. Breast Cancer Research and Treatment 86(1), 75-88 (2004). doi: 10.1023/B:BREA.0000032926.74216.7D. 2003Gillissen B, Essmann F, Graupner V, Stärck L, Radetzki S, Dörken B, Schulze-Osthoff K, Daniel PT. Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway. EMBO Journal 22(14), 3580-3590 (2003). doi: 10.1093/EMBOJ/CDG343.Von Haefen C, Wieder T, Essmann F, Schulze-Osthoff K, Dörken B, Daniel PT. Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop. Oncogene 22(15), 2236-2247 (2003). doi: 10.1038/SJ.ONC.1206280.Essmann F, Bantel H, Totzke G, Engels IH, Sinha B, Schulze-Osthoff K, Jänicke RU. Staphylococcus aureus α-toxin-induced cell death: Predominant necrosis despite apoptotic caspase activation. Cell Death and Differentiation 10(11), 1260-1272 (2003). doi: 10.1038/SJ.CDD.4401301.Zeller M, Essmann F, Jänicke RU, Schulze-Osthoff K, König S. A rapid nonradioactive peptide phosphorylation assay. Journal of Experimental Therapeutics and Oncology 3(2), 59-61 (2003). doi: 10.1046/J.1359-4117.2003.01074.X.Monroe DG, Getz BJ, Johnsen SA, Riggs BL, Khosla S, Spelsberg TC. Estrogen receptor isoform-specific regulation of endogenous gene expression in human osteoblastic cell lines expressing either ERα or ERβ. Journal of Cellular Biochemistry 90(2), 315-326 (2003). doi: 10.1002/JCB.10633.Monroe DG, Johnsen SA, Subramaniam M, Getz BJ, Khosla S, Riggs BL, Spelsberg TC. Mutual antagonism of estrogen receptors α and β and their preferred interactions with steroid receptor coactivators in human osteoblastic cell lines. Journal of Endocrinology 176(3), 349-357 (2003). doi: 10.1677/JOE.0.1760349. 2002Bosanquet AG, Sturm I, Wieder T, Essmann F, Bosanquet MI, Head DJ, Dörken B, Daniel PT. Bax expression correlates with cellular drug sensitivity to doxorubicin, cyclophosphamide and chlorambucil but not fludarabine, cladribine or corticosteroids in B cell chronic lymphocytic leukemia. Leukemia 16(6), 1035-1044 (2002). doi: 10.1038/SJ.LEU.2402539.Johnsen SA, Subramaniam M, Janknecht R, Spelsberg TC. TGFβ inducible early gene enhances TGFβ/Smad-dependent transcriptional responses. Oncogene 21(37), 5783-5790 (2002). doi: 10.1038/SJ.ONC.1205681.Johnsen SA, Subramaniam M, Monroe DG, Janknecht R, Spelsberg TC. Modulation of transforming growth factor β (TGFβ)/Smad transcriptional responses through targeted degradation of TGFβ-inducible early gene-1 by human seven in absentia homologue. Journal of Biological Chemistry 277(34), 30754-30759 (2002). doi: 10.1074/JBC.M204812200.Johnsen SA, Subramaniam M, Katagiri T, Janknecht R, Spelsberg TC. Transcriptional regulation of Smad2 is required for enhancement of TGFβ/Smad signaling by TGFβ inducible early gene. Journal of Cellular Biochemistry 87(2), 233-241 (2002). doi: 10.1002/JCB.10299. 2001Wieder T, Essmann F, Prokop A, Schmelz K, Schulze-Osthoff K, Beyaert R, Dörken B, Daniel PT. Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3. Blood 97(5), 1378-1387 (2001). doi: 10.1182/BLOOD.V97.5.1378.Wieder T, Prokop A, Bagci B, Essmann F, Bernicke D, Schulze-Osthoff K, Dörken B, Schmalz HG, Daniel PT, Henze G. Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts. Leukemia 15(11), 1735-1742 (2001). doi: 10.1038/SJ.LEU.2402284. 2000Prokop A, Wieder T, Sturm I, Eßmann F, Seeger K, Wuchter C, Ludwig W, Henze G, Dörken B, Daniel PT. Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the Bax/Bcl-2 ratio and loss of spontaneous caspase-3 processing in vivo. Leukemia 14(9), 1606-1613 (2000). doi: 10.1038/sj.leu.2401866.Hefferan TE, Reinholz GG, Rickard DJ, Johnsen SA, Waters KM, Subramaniam M, Speisberg TC. Overexpression of a nuclear protein, TIEG, mimics transforming growth factor-β action in human osteoblast cells. Journal of Biological Chemistry 275(27), 20255-20259 (2000). doi: 10.1074/JBC.C000135200. 1999Daniel PT, Scholz C, Eßmann F, Westermann J, Pezzutto A, Dörken B. CD95/Fas-triggered apoptosis of activated T lymphocytes is prevented by dendritic cells through a CD58-dependent mechanism. Experimental Hematology 27(9), 1402-1408 (1999). doi: 10.1016/S0301-472X(99)00079-X.
